RT Journal Article
SR Electronic
T1 GLR-1, a Non-NMDA Glutamate Receptor Homolog, Is Critical for Long-Term Memory in <em>Caenorhabditis elegans</em>
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9595
OP 9599
DO 10.1523/JNEUROSCI.23-29-09595.2003
VO 23
IS 29
A1 Rose, Jacqueline K.
A1 Kaun, Karla R.
A1 Chen, Sylvia H.
A1 Rankin, Catharine H.
YR 2003
UL http://www.jneurosci.org/content/23/29/9595.abstract
AB Long-term memory for habituation to tap in Caenorhabditis elegans depends on glr-1, a homolog of mammalian non-NMDA glutamate receptors; mutations in glr-1 blocked long-term memory formation. Green fluorescent protein (GFP) constructs were used to visualize glr-1 expression in the interneurons of the mechanosensory circuit and synaptobrevin in the tap sensory neurons of trained and untrained worms. Trained animals had less GLR-1::GFP expression than untrained animals; there was no difference in the vesicle marker synaptobrevin. Heat shock during training blocked both the behavioral expression of long-term memory and the change in GLR-1::GFP expression. Thus, long-term memory in C. elegans is dependent on glr-1 and likely involves changes in the expression or localization of glutamate receptors.