PT  - JOURNAL ARTICLE
AU  - Wen-Jun Gao
AU  - Yun Wang
AU  - Patricia S. Goldman-Rakic
TI  - Dopamine Modulation of Perisomatic and Peridendritic Inhibition in Prefrontal Cortex
AID  - 10.1523/JNEUROSCI.23-05-01622.2003
DP  - 2003 Mar 01
TA  - The Journal of Neuroscience
PG  - 1622--1630
VI  - 23
IP  - 5
4099  - http://www.jneurosci.org/content/23/5/1622.short
4100  - http://www.jneurosci.org/content/23/5/1622.full
SO  - J. Neurosci.2003 Mar 01; 23
AB  - The computations underlying cognitive functions are performed by a diversity of interactions between interneurons and pyramidal neurons that are subject to modulatory influences. Here we have used paired whole-cell recording to study the influence of dopamine on local inhibitory circuits involving fast-spiking (FS) and non-FS cells, respectively. We found that dopamine depressed inhibitory transmission between FS interneurons and pyramidal neurons but enhanced inhibition between non-FS interneurons and pyramidal cells. FS inhibitory transmission exhibited properties associated with presynaptic action at D1 receptors that were not evident in non-FS inhibitory connections. In addition, FS and non-FS interneurons differed morphologically, forming contacts on the perisomatic and peridendritic domains, respectively, of their pyramidal cell targets. These findings provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine.