TY - JOUR T1 - Glutamate Spillover in the Striatum Depresses Dopaminergic Transmission by Activating Group I Metabotropic Glutamate Receptors JF - The Journal of Neuroscience JO - J. Neurosci. SP - 10585 LP - 10592 DO - 10.1523/JNEUROSCI.23-33-10585.2003 VL - 23 IS - 33 AU - Hui Zhang AU - David Sulzer Y1 - 2003/11/19 UR - http://www.jneurosci.org/content/23/33/10585.abstract N2 - Cortical glutamate and substantia nigra dopamine (DA) afferents converge onto the dendritic spines of medium spiny neurons (MSNs) in the striatum where they act to modulate motor and cognitive functions. The released DA spills over from its synapse and is thought to regulate glutamatergic input by acting on distal DA receptors located on corticostriatal axon terminals. By monitoring evoked DA release directly using fast-scan cyclic voltammetry, we report a reciprocal modulation by glutamate spillover on evoked striatal DA release, induced by either glutamate uptake blockade or high-frequency stimulation of corticostriatal tracts. We demonstrate that this modulation is attributable to the activation of group I metabotropic glutamate receptors. Thus, under conditions in which glutamate escapes the confines of its synapse, it can elicit the presynaptic suppression of dopaminergic neurotransmission. ER -