TY - JOUR T1 - Temporal Properties of Cerebellar-Dependent Memory Consolidation JF - The Journal of Neuroscience JO - J. Neurosci. SP - 2934 LP - 2941 DO - 10.1523/JNEUROSCI.5505-03.2004 VL - 24 IS - 12 AU - Samuel F. Cooke AU - Phillip J. E. Attwell AU - Christopher H. Yeo Y1 - 2004/03/24 UR - http://www.jneurosci.org/content/24/12/2934.abstract N2 - Classical conditioning of the nictitating membrane response in rabbits is a well defined model of cerebellar-dependent motor memory. This memory undergoes a period of consolidation after the training session, when it is sensitive to reversible inactivations of the cerebellar cortex, but not of the cerebellar nuclei, with the GABAA receptor agonist muscimol. Here, the temporal properties of this cerebellar cortex-dependent consolidation were examined using delayed infusions of muscimol in cortical lobule HVI. Cortical infusions delayed by 5 or 45 min after a conditioning session produced significant and very similar impairments of consolidation, but infusions delayed by 90 min produced little or no impairment. Behavioral measures indicate that the muscimol infusions produced significant effects after ∼30 min and they lasted for a few hours. So, over a time window beginning ∼1 hr after the end of the training session and closing 1 hr after that, intracortical activity is critical for consolidation of this motor memory. ER -