RT Journal Article
SR Electronic
T1 Discovering Spike Patterns in Neuronal Responses
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2989
OP 3001
DO 10.1523/JNEUROSCI.4649-03.2004
VO 24
IS 12
A1 Jean-Marc Fellous
A1 Paul H. E. Tiesinga
A1 Peter J. Thomas
A1 Terrence J. Sejnowski
YR 2004
UL http://www.jneurosci.org/content/24/12/2989.abstract
AB When a cortical neuron is repeatedly injected with the same fluctuating current stimulus (frozen noise) the timing of the spikes is highly precise from trial to trial and the spike pattern appears to be unique. We show here that the same repeated stimulus can produce more than one reliable temporal pattern of spikes. A new method is introduced to find these patterns in raw multitrial data and is tested on surrogate data sets. Using it, multiple coexisting spike patterns were discovered in pyramidal cells recorded from rat prefrontal cortex in vitro, in data obtained in vivo from the middle temporal area of the monkey (Buracas et al., 1998) and from the cat lateral geniculate nucleus (Reinagel and Reid, 2002). The spike patterns lasted from a few tens of milliseconds in vitro to several seconds in vivo. We conclude that the prestimulus history of a neuron may influence the precise timing of the spikes in response to a stimulus over a wide range of time scales.