RT Journal Article
SR Electronic
T1 Noradrenaline and Dopamine Efflux in the Prefrontal Cortex in Relation to Appetitive Classical Conditioning
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2475
OP 2480
DO 10.1523/JNEUROSCI.4547-03.2004
VO 24
IS 10
A1 Mingote, Susana
A1 de Bruin, Jan P. C.
A1 Feenstra, Matthijs G. P.
YR 2004
UL http://www.jneurosci.org/content/24/10/2475.abstract
AB We trained rats to learn that an auditory stimulus predicted delivery of reward pellets in the Skinner box. After 2 d of training, we measured changes in efflux of noradrenaline (NA) and dopamine (DA) in the medial prefrontal cortex using microdialysis on the third day. Animals were subjected to a normal rewarded session and an extinction session, in which the auditory stimulus was presented alone. In the rewarded session, both NA and DA efflux were increased, but in extinction, only NA was activated. The data suggest that NA has a role in the reaction to reward-predicting stimuli, which complements that of DA.