TY - JOUR T1 - Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic Mice JF - The Journal of Neuroscience JO - J. Neurosci. SP - 4692 LP - 4697 DO - 10.1523/JNEUROSCI.0277-04.2004 VL - 24 IS - 19 AU - Jeannie Chin AU - Jorge J. Palop AU - Gui-Qiu Yu AU - Nobuhiko Kojima AU - Eliezer Masliah AU - Lennart Mucke Y1 - 2004/05/12 UR - http://www.jneurosci.org/content/24/19/4692.abstract N2 - Alzheimer's disease (AD), the most common neurodegenerative disorder, results in progressive degeneration of synapses and aberrant sprouting of axon terminals. The mechanisms underlying these seemingly opposing cellular phenomena are unclear. We hypothesized that Fyn kinase may play a role in one or both of these processes because it is increased in AD brains and because it is involved in synaptic plasticity and axonal outgrowth. We investigated the effects of Fyn on AD-related synaptotoxicity and aberrant axonal sprouting by ablating or overexpressing Fyn in human amyloid precursor protein (hAPP) transgenic mice. On the fyn+/+ background, hAPP/amyloid β peptide (Aβ) decreased hippocampal levels of synaptophysin-immunoreactive presynaptic terminals (SIPTs), consistent with previous findings. On the fyn-/- background, hAPP/Aβ did not affect SIPTs. SIPT reductions correlated with hippocampal Aβ levels in hAPP/fyn+/+, but not hAPP/fyn-/-, mice suggesting that Fyn provides a critical link between hAPP/Aβ and SIPTs. Furthermore, overexpression of Fyn exacerbated SIPT reductions in hAPP mice. We also found that the susceptibility of mice to hAPP/Aβ-induced premature mortality was decreased by Fyn ablation and increased by Fyn overexpression. In contrast, axonal sprouting in the hippocampus of hAPP mice was unaffected. We conclude that Fyn-dependent pathways are critical in AD-related synaptotoxicity and that the pathogenesis of hAPP/Aβ-induced neuronal alterations may be mechanistically heterogenous. ER -