RT Journal Article SR Electronic T1 Removal of AMPA Receptors (AMPARs) from Synapses Is Preceded by Transient Endocytosis of Extrasynaptic AMPARs JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 5172 OP 5176 DO 10.1523/JNEUROSCI.1042-04.2004 VO 24 IS 22 A1 Michael C. Ashby A1 Sarah A. De La Rue A1 G. Scott Ralph A1 James Uney A1 Graham L. Collingridge A1 Jeremy M. Henley YR 2004 UL http://www.jneurosci.org/content/24/22/5172.abstract AB AMPA receptors (AMPARs) are dynamically regulated at synapses, but the time course and location of their exocytosis and endocytosis are not known. Therefore, we have used ecliptic pHluorin-tagged glutamate receptor 2 to visualize changes in AMPAR surface expression in real time. We show that synaptic and extrasynaptic AMPARs respond very differently to NMDA receptor activation; there is a rapid internalization of extrasynaptic AMPARs that precedes the delayed removal of synaptic AMPARs.