RT Journal Article
SR Electronic
T1 Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT<sub>4</sub> Receptor Knock-Out Mice
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 412
OP 419
DO 10.1523/JNEUROSCI.2806-03.2004
VO 24
IS 2
A1 Valérie Compan
A1 Mingming Zhou
A1 Régis Grailhe
A1 Russell A. Gazzara
A1 Renee Martin
A1 Jay Gingrich
A1 Aline Dumuis
A1 Daniela Brunner
A1 Joël Bockaert
A1 René Hen
YR 2004
UL http://www.jneurosci.org/content/24/2/412.abstract
AB To study the functions of 5-HT4 receptors, a null mutation was engineered in the corresponding gene. 5-HT4 receptor knock-out mice displayed normal feeding and motor behaviors in baseline conditions but abnormal feeding and locomotor behavior in response to stress and novelty. Specifically, stress-induced hypophagia and novelty-induced exploratory activity were attenuated in the knock-out mice. In addition, pentylenetetrazol-induced convulsive responses were enhanced in the knock-out mice, suggesting an increase in neuronal network excitability. These results provide the first example of a genetic deficit that disrupts the ability of stress to reduce feeding and body weight and suggest that 5-HT4 receptors may be involved in stress-induced anorexia and seizure susceptibility.