RT Journal Article
SR Electronic
T1 The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 10099
OP 10102
DO 10.1523/JNEUROSCI.2680-04.2004
VO 24
IS 45
A1 Pezawas, Lukas
A1 Verchinski, Beth A.
A1 Mattay, Venkata S.
A1 Callicott, Joseph H.
A1 Kolachana, Bhaskar S.
A1 Straub, Richard E.
A1 Egan, Michael F.
A1 Meyer-Lindenberg, Andreas
A1 Weinberger, Daniel R.
YR 2004
UL http://www.jneurosci.org/content/24/45/10099.abstract
AB A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.