TY - JOUR T1 - Requirement of Nicotinic Acetylcholine Receptor Subunit β2 in the Maintenance of Spiral Ganglion Neurons during Aging JF - The Journal of Neuroscience JO - J. Neurosci. SP - 3041 LP - 3045 DO - 10.1523/JNEUROSCI.5277-04.2005 VL - 25 IS - 12 AU - Jianxin Bao AU - Debin Lei AU - Yafei Du AU - Kevin K. Ohlemiller AU - Arthur L. Beaudet AU - Lorna W. Role Y1 - 2005/03/23 UR - http://www.jneurosci.org/content/25/12/3041.abstract N2 - Age-related hearing loss (presbycusis) is a major health concern for the elderly. Loss of spiral ganglion neurons (SGNs), the primary sensory relay of the auditory system, is associated consistently with presbycusis. The causative molecular events responsible for age-related loss of SGNs are unknown. Recent reports directly link age-related neuronal loss in cerebral cortex with the loss of high-affinity nicotine acetylcholine receptors (nAChRs). In cochlea, cholinergic synapses are made by olivocochlear efferent fibers on the outer hair cells that express α9 nAChR subunits and on the peripheral projections of SGNs that express α2, α4-7, and β2-3 nAChR subunits. A significantly decreased expression of the β2 nAChR subunit in SGNs was found specifically in mice susceptible to presbycusis. Furthermore, mice lacking the β2 nAChR subunit (β2-/-), but not mice lacking the α5 nAChR subunit (α5-/-), have dramatic hearing loss and significant reduction in the number of SGNs. Our findings clearly established a requirement for β2 nAChR subunit in the maintenance of SGNs during aging. ER -