RT Journal Article
SR Electronic
T1 A Dissociation of Encoding and Retrieval Processes in the Human Hippocampus
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 3280
OP 3286
DO 10.1523/JNEUROSCI.3420-04.2005
VO 25
IS 13
A1 Eldridge, Laura L.
A1 Engel, Stephen A.
A1 Zeineh, Michael M.
A1 Bookheimer, Susan Y.
A1 Knowlton, Barbara J.
YR 2005
UL http://www.jneurosci.org/content/25/13/3280.abstract
AB The hippocampal formation performs two related but distinct memory functions: encoding of novel information and retrieval of episodes. Little evidence, however, resolves how these two processes are implemented within the same anatomical structure. Here we use high-resolution functional magnetic resonance imaging to show that distinct subregions of the hippocampus are differentially involved in encoding and retrieval. We found that regions early in the hippocampal circuit (dentate gyrus and CA fields 2 and 3) were selectively active during episodic memory formation, whereas a region later in the circuit (the subiculum) was active during the recollection of the learning episode. Different components of the hippocampal circuit likely contribute to different degrees to the two basic memory functions.