RT Journal Article
SR Electronic
T1 Glutamate Receptors in Perirhinal Cortex Mediate Encoding, Retrieval, and Consolidation of Object Recognition Memory
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 4243
OP 4251
DO 10.1523/JNEUROSCI.0480-05.2005
VO 25
IS 17
A1 Boyer D. Winters
A1 Timothy J. Bussey
YR 2005
UL http://www.jneurosci.org/content/25/17/4243.abstract
AB Object recognition is consistently impaired in human amnesia and animal models thereof. Results from subjects with permanent brain damage have revealed the importance of the perirhinal cortex to object recognition memory. Here, we report evidence from rats for interdependent but distinct stages in object recognition memory (encoding, retrieval, and consolidation), which require glutamate receptor activity within perirhinal cortex. Transient blockade of AMPA receptor-mediated synaptic transmission within perirhinal cortex disrupted encoding for short- and long-term memory as well as retrieval and consolidation. In contrast, transient NMDA receptor blockade during encoding affected only long-term object recognition memory; NMDA receptor activity was also necessary for consolidation but not retrieval. These results further demonstrate the importance of perirhinal cortex for object recognition memory and suggest that, as in the hippocampus, AMPA and NMDA receptors mediate synaptic transmission and activity-dependent synaptic plasticity, respectively, in several stages of memory processing.