RT Journal Article
SR Electronic
T1 Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 1304
OP 1310
DO 10.1523/JNEUROSCI.4745.04.2005
VO 25
IS 5
A1 Lee, Hyosang
A1 Iida, Tohko
A1 Mizuno, Atsuko
A1 Suzuki, Makoto
A1 Caterina, Michael J.
YR 2005
UL http://www.jneurosci.org/content/25/5/1304.abstract
AB Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4-/- mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia. However, it is unknown whether TRPV4 or related transient receptor potential channels account for warmth perception under injury-free conditions. We therefore investigated the contribution of TRPV4 to thermosensation and thermoregulation in vivo. On a thermal gradient, TRPV4-/- mice selected warmer floor temperatures than wild-type littermates. In addition, whereas wild-type mice failed to discriminate between floor temperatures of 30 and 34°C, TRPV4-/- mice exhibited a strong preference for 34°C. TRPV4-/- mice also exhibited prolonged withdrawal latencies during acute tail heating. TRPV4-/- and wild-type mice exhibited similar changes in behavior on a thermal gradient after paw inflammation. Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness in vivo.