TY - JOUR T1 - Maternal Stress Produces Learning Deficits Associated with Impairment of NMDA Receptor-Mediated Synaptic Plasticity JF - The Journal of Neuroscience JO - J. Neurosci. SP - 3309 LP - 3318 DO - 10.1523/JNEUROSCI.3850-05.2006 VL - 26 IS - 12 AU - Gi Hoon Son AU - Dongho Geum AU - Sooyoung Chung AU - Eun Joo Kim AU - Ji-Hoon Jo AU - Chang-Mee Kim AU - Kun Ho Lee AU - Hyun Kim AU - Sukwoo Choi AU - Hyun Taek Kim AU - Chang-Joong Lee AU - Kyungjin Kim Y1 - 2006/03/22 UR - http://www.jneurosci.org/content/26/12/3309.abstract N2 - Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affects the brain function of offspring when they are adult remains primarily unknown. In the present work, chronic immobilization stress to pregnant mice affected fetal growth and development. When pups born from stressed mice were reared to adulthood in an environment identical to that of nonstressed controls, several physiological parameters were essentially unaltered. However, spatial learning and memory was significantly impaired in the maternally stressed offspring in adulthood. Furthermore, electrophysiological examination revealed a significant reduction in NMDA receptor-mediated long-term potentiation in the CA1 area of hippocampal slices. Subsequent biochemical analysis demonstrated a substantial decrease in NR1 and NR2B subunits of the NMDA receptor in synapses of the hippocampus, and the interaction between these two subunits appeared to be reduced. These results suggest that prolonged maternal stress leads to long-lasting malfunction of the hippocampus, which extends to and is manifested in adulthood. ER -