RT Journal Article SR Electronic T1 Cue-Induced Cocaine Seeking and Relapse Are Reduced by Disruption of Drug Memory Reconsolidation JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 5881 OP 5887 DO 10.1523/JNEUROSCI.0323-06.2006 VO 26 IS 22 A1 Lee, Jonathan L. C. A1 Milton, Amy L. A1 Everitt, Barry J. YR 2006 UL http://www.jneurosci.org/content/26/22/5881.abstract AB Long-lasting vulnerability to drug cue-induced relapse to a drug-taking habit is a major challenge to the treatment of drug addiction. Here we show that blockade of drug memory reconsolidation, through infusion of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala shortly before reexposure to a cocaine-associated stimulus but not simply to the training context, severely impaired subsequently cue-maintained cocaine seeking under a second-order schedule of reinforcement and abolished cue-induced reinstatement of and relapse to cocaine seeking. This reduction in relapse after disrupted memory reconsolidation was not only seen after several hundred pairings of the stimulus with self-administered cocaine, but older, as well as recent, memories were also disrupted. Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction.