TY - JOUR T1 - Essential Role of the Hippocampal Formation in Rapid Learning of Higher-Order Sequential Associations JF - The Journal of Neuroscience JO - J. Neurosci. SP - 4111 LP - 4117 DO - 10.1523/JNEUROSCI.0441-06.2006 VL - 26 IS - 15 AU - Ceren Ergorul AU - Howard Eichenbaum Y1 - 2006/04/12 UR - http://www.jneurosci.org/content/26/15/4111.abstract N2 - Evidence from studies of amnesia and functional imaging in humans suggest that the medial temporal lobe is involved in the learning of higher-order sequences during acquisition of serial reaction time (SRT) tasks. However, these studies have not clarified whether the hippocampal formation specifically is essential to this type of learning. Here, we developed a rodent model of the SRT task to examine the specific roles of the hippocampal formation in learning first- and second-order conditional sequences. Selective hippocampal formation lesions speeded performance and impaired accuracy on both first- and second-order sequences. Additionally, whereas controls distinguished the sequences based on their complexity alone, animals with hippocampal lesions initially differentiated sequences only by their length. Over multiple sessions, hippocampal rats gradually differentiated sequences by their complexity and not length, similar to control subjects. These findings indicate that the hippocampal formation itself plays an essential role in rapid acquisition of higher-order sequence representations. Extrahippocampal systems can also acquire complex sequential representations, albeit via a gradual learning mechanism. ER -