PT  - JOURNAL ARTICLE
AU  - Hirokawa, Nobutaka
TI  - mRNA Transport in Dendrites: RNA Granules, Motors, and Tracks
AID  - 10.1523/JNEUROSCI.1821-06.2006
DP  - 2006 Jul 05
TA  - The Journal of Neuroscience
PG  - 7139--7142
VI  - 26
IP  - 27
4099  - http://www.jneurosci.org/content/26/27/7139.short
4100  - http://www.jneurosci.org/content/26/27/7139.full
SO  - J. Neurosci.2006 Jul 05; 26
AB  - The targeting of mRNAs to neuronal dendrites is an important protein sorting mechanism. Recent studies have revealed that mRNAs are transported by molecular motors. The kinesin superfamily protein KIF5 transports mRNAs such as calcium/calmodulin-dependent kinase IIα (CaMKIIα) and Arc mRNAs along microtubules in large granules containing proteins involved in RNA transport, protein synthesis, RNA helicases, heterogeneous nuclear ribonucleoproteins (hnRNPs), and RNA-associated proteins. This transport is fundamental to local protein synthesis and to the regulation of neuronal function.