PT  - JOURNAL ARTICLE
AU  - Y. M. Lisa Chuah
AU  - Vinod Venkatraman
AU  - David F. Dinges
AU  - Michael W. L. Chee
TI  - The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation
AID  - 10.1523/JNEUROSCI.0906-06.2006
DP  - 2006 Jul 05
TA  - The Journal of Neuroscience
PG  - 7156--7162
VI  - 26
IP  - 27
4099  - http://www.jneurosci.org/content/26/27/7156.short
4100  - http://www.jneurosci.org/content/26/27/7156.full
SO  - J. Neurosci.2006 Jul 05; 26
AB  - Sleep deprivation results in the loss of our ability to suppress a prepotent response. The extent of decline in this executive function varies across individuals. Here, we used functional magnetic resonance imaging to study the neural correlates of sleep deprivation-induced differences in inhibitory efficiency. Participants performed a go/no-go task after normal sleep and after 24 h of total sleep deprivation. Regardless of the extent of change in inhibitory efficiency, sleep deprivation lowered go/no-go sustained, task-related activation of the ventral and anterior prefrontal (PFC) regions bilaterally. However, individuals better able to maintain inhibitory efficiency after sleep deprivation could be distinguished by lower stop-related, phasic activation of the right ventral PFC during rested wakefulness. These persons also showed a larger rise in such activation both here and in the right insula after sleep deprivation relative to those whose inhibitory efficiency declined.