TY - JOUR T1 - The Role of Multiple Contralesional Motor Areas for Complex Hand Movements after Internal Capsular Lesion JF - The Journal of Neuroscience JO - J. Neurosci. SP - 6096 LP - 6102 DO - 10.1523/JNEUROSCI.4564-05.2006 VL - 26 IS - 22 AU - Martin Lotze AU - Jochen Markert AU - Paul Sauseng AU - Julia Hoppe AU - Christian Plewnia AU - Christian Gerloff Y1 - 2006/05/31 UR - http://www.jneurosci.org/content/26/22/6096.abstract N2 - Imaging techniques document enhanced activity in multiple motor areas of the damaged and contralesional (intact) hemisphere (CON-H) after stroke. In the subacute stage, increased activity within motor areas in the CON-H during simple movements of the affected hand has been shown to correlate with poorer motor outcome. For those patients in the chronic stage who recovered well, the functional relevance of an increased activation within the CON-H is unclear. Using trains of repetitive transcranial magnetic stimulation (TMS) during performance of complex finger movements, we tested the behavioral relevance of regional functional magnetic resonance imaging (fMRI) activation within the CON-H for sequential finger movement performance of the recovered hand in seven patients who had experienced a subcortical stroke. TMS was navigated over fMRI activation maxima within anatomically preselected regions of the CON-H, and effects were compared with those of healthy controls. Stimulation over the dorsal premotor cortex (dPMC), the primary motor cortex (M1), and the superior parietal lobe (SPL) resulted in significant interference with recovered performance in patients. Interference with the dPMC and M1 induced timing errors only, SPL stimulation caused both timing and accuracy deficits. The present results argue for a persistent beneficial role of the dPMC, M1, and SPL of the CON-H on some aspects of effectively recovered complex motor behavior after subcortical stroke. ER -