RT Journal Article
SR Electronic
T1 Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6627
OP 6636
DO 10.1523/JNEUROSCI.0149-06.2006
VO 26
IS 24
A1 Yamashita, Toru
A1 Ninomiya, Mikiko
A1 Hernández Acosta, Pilar
A1 García-Verdugo, Jose Manuel
A1 Sunabori, Takehiko
A1 Sakaguchi, Masanori
A1 Adachi, Kazuhide
A1 Kojima, Takuro
A1 Hirota, Yuki
A1 Kawase, Takeshi
A1 Araki, Nobuo
A1 Abe, Koji
A1 Okano, Hideyuki
A1 Sawamoto, Kazunobu
YR 2006
UL http://www.jneurosci.org/content/26/24/6627.abstract
AB Recent studies have revealed that the adult mammalian brain has the capacity to regenerate some neurons after various insults. However, the precise mechanism of insult-induced neurogenesis has not been demonstrated. In the normal brain, GFAP-expressing cells in the subventricular zone (SVZ) of the lateral ventricles include a neurogenic cell population that gives rise to olfactory bulb neurons only. Herein, we report evidence that, after a stroke, these cells are capable of producing new neurons outside the olfactory bulbs. SVZ GFAP-expressing cells labeled by a cell-type-specific viral infection method were found to generate neuroblasts that migrated toward the injured striatum after middle cerebral artery occlusion. These neuroblasts in the striatum formed elongated chain-like cell aggregates similar to those in the normal SVZ, and these chains were observed to be closely associated with thin astrocytic processes and blood vessels. Finally, long-term tracing of the green fluorescent-labeled cells with a Cre-loxP system revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells. These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders.