RT Journal Article
SR Electronic
T1 Encoding and Decoding Touch Location in the Leech CNS
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 8009
OP 8016
DO 10.1523/JNEUROSCI.5472-05.2006
VO 26
IS 30
A1 Eric E. Thomson
A1 William B. Kristan
YR 2006
UL http://www.jneurosci.org/content/26/30/8009.abstract
AB Spike times encode stimulus values in many sensory systems, but it is generally unknown whether such temporal variations are decoded (i.e., whether they influence downstream networks that control behavior). In the present study, we directly address this decoding problem by quantifying both sensory encoding and decoding in the leech. By mechanically stimulating the leech body wall while recording from mechanoreceptors, we show that pairs of leech sensory neurons with overlapping receptive fields encode touch location by their relative latencies, number of spikes, and instantaneous firing rates, with relative latency being the most accurate indicator of touch location. We then show that the relative latency and count are decoded by manipulating these variables in sensory neuron pairs while simultaneously monitoring the resulting behavior. Although both variables are important determinants of leech behavior, the decoding mechanisms are more sensitive to changes in relative spike count than changes in relative latency.