PT  - JOURNAL ARTICLE
AU  - David J. Solecki
AU  - Eve-Ellen Govek
AU  - Mary E. Hatten
TI  - mPar6α Controls Neuronal Migration
AID  - 10.1523/JNEUROSCI.4060-06.2006
DP  - 2006 Oct 18
TA  - The Journal of Neuroscience
PG  - 10624--10625
VI  - 26
IP  - 42
4099  - http://www.jneurosci.org/content/26/42/10624.short
4100  - http://www.jneurosci.org/content/26/42/10624.full
SO  - J. Neurosci.2006 Oct 18; 26
AB  - We review studies on the polarity of developing cerebellar granule, showing that the centrosome localizes to the pole of the neuron that extrudes the nascent axon, and the Rho GTPase Cdc42 (cell division cycle 42) activates the mPar6α/Par3 (Par for partitioning defective) complex to coordinate actin dynamics in the growth cone. Subsequently, mPar6α signaling controls the migration of immature granule neurons down the Bergmann glial fibers into the internal granule cell layer in which they establish synaptic connections.