PT  - JOURNAL ARTICLE
AU  - César Quiroz
AU  - Catarina Gomes
AU  - Arlene C. Pak
AU  - Joaquim A. Ribeiro
AU  - Steven R. Goldberg
AU  - Bruce T. Hope
AU  - Sergi Ferré
TI  - Blockade of Adenosine A<sub>2A</sub> Receptors Prevents Protein Phosphorylation in the Striatum Induced by Cortical Stimulation
AID  - 10.1523/JNEUROSCI.1661-06.2006
DP  - 2006 Oct 18
TA  - The Journal of Neuroscience
PG  - 10808--10812
VI  - 26
IP  - 42
4099  - http://www.jneurosci.org/content/26/42/10808.short
4100  - http://www.jneurosci.org/content/26/42/10808.full
SO  - J. Neurosci.2006 Oct 18; 26
AB  - Previous studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons. In the present study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A receptor antagonist counteracts the striatal activation of cAMP–protein kinase A cascade (phosphorylation of the Ser845 residue of the glutamate receptor 1 subunit of the AMPA receptor) and mitogen-activated protein kinase (ERK1/2 phosphorylation) induced by the in vivo stimulation of corticostriatal afferents. The results indicate that A2A receptors strongly modulate the efficacy of glutamatergic synapses on striatal enkephalinergic neurons.