RT Journal Article SR Electronic T1 Altered Hippocampal Synaptic Potentiation in P2X4 Knock-Out Mice JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 9006 OP 9009 DO 10.1523/JNEUROSCI.2370-06.2006 VO 26 IS 35 A1 Sim, Joan A. A1 Chaumont, Séverine A1 Jo, Jihoon A1 Ulmann, Lauriane A1 Young, Mark T. A1 Cho, Kwangwook A1 Buell, Gary A1 North, R. Alan A1 Rassendren, Francois YR 2006 UL http://www.jneurosci.org/content/26/35/9006.abstract AB P2X4 purinergic receptors are calcium-permeable, ATP-activated ion channels. In the CA1 area of the hippocampus, they are located at the subsynaptic membrane somewhat peripherally to AMPA receptors. The possible role of P2X4 receptors has been difficult to elucidate because of the lack of selective antagonists. Here we report the generation of a P2X4 receptor knock-out mouse and show that long-term potentiation (LTP) at Schaffer collateral synapses is reduced relative to that in wild-type mice. Ivermectin, which selectively potentiates currents at P2X4, was found to increase LTP in wild-type mice but had no effect in P2X4 knock-out mice. We suggest that calcium entry through subsynaptic P2X4 receptors during high-frequency stimulation contributes to synaptic strengthening.