RT Journal Article
SR Electronic
T1 The Activation of Excitatory Glutamate Receptors Evokes a Long-Lasting Increase in the Release of GABA from Cerebellar Stellate Cells
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9332
OP 9339
DO 10.1523/JNEUROSCI.2929-06.2006
VO 26
IS 36
A1 Siqiong June Liu
A1 Philippe Lachamp
YR 2006
UL http://www.jneurosci.org/content/26/36/9332.abstract
AB The excitability of a neuron is regulated by the balance of excitatory and inhibitory inputs that impinge on it. Such modulation can occur either presynaptically or postsynaptically. Here, we show that an excitatory transmitter can increase the release of an inhibitory transmitter and thus paradoxically produces a long-lasting enhancement of inhibitory synaptic transmission. This occurs at a near-physiological temperature. These findings from cerebellar stellate neurons reveal a novel form of long-term potentiation that is induced by the activation of NMDA-type glutamate receptors and that requires both glutamate and glycine. Our results indicate that Ca2+ entry into the presynaptic terminals during the activation of presynaptic NMDARs is necessary to induce the potentiation. This presynaptic modulation provides a mechanism by which an excitatory transmitter can induce a long-term increase in the release of an inhibitory transmitter and thus modify the activity of a simple neuronal circuit.