RT Journal Article
SR Electronic
T1 Biophysical Model of AMPA Receptor Trafficking and Its Regulation during Long-Term Potentiation/Long-Term Depression
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 12362
OP 12373
DO 10.1523/JNEUROSCI.3601-06.2006
VO 26
IS 47
A1 Earnshaw, Berton A.
A1 Bressloff, Paul C.
YR 2006
UL http://www.jneurosci.org/content/26/47/12362.abstract
AB AMPA receptors mediate the majority of fast excitatory synaptic transmission in the CNS, and evidence suggests that AMPA receptor trafficking regulates synaptic strength, a phenomenon implicated in learning and memory. There are two major mechanisms of AMPA receptor trafficking: exocytic/endocytic exchange of surface receptors with intracellular receptor pools, and the lateral diffusion or hopping of surface receptors between the postsynaptic density and the surrounding extrasynaptic membrane. In this paper, we present a biophysical model of these trafficking mechanisms under basal conditions and during the expression of long-term potentiation (LTP) and depression (LTD). We show how our model reproduces a wide range of physiological data, and use this to make predictions regarding possible targets of second-messenger pathways activated during the induction phase of LTP/LTD.