RT Journal Article
SR Electronic
T1 A Sex-Specific Role of Type VII Adenylyl Cyclase in Depression
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 12609
OP 12619
DO 10.1523/JNEUROSCI.1040-06.2006
VO 26
IS 48
A1 Lisa M. Hines
A1 Paula L. Hoffman
A1 Sanjiv Bhave
A1 Laura Saba
A1 Alan Kaiser
A1 Larry Snell
A1 Igor Goncharov
A1 Lucie LeGault
A1 Maurice Dongier
A1 Bridget Grant
A1 Sergey Pronko
A1 Larry Martinez
A1 Masami Yoshimura
A1 Boris Tabakoff
YR 2006
UL http://www.jneurosci.org/content/26/48/12609.abstract
AB Major depression represents a complex mental disorder. The identification of biological markers that define subtypes of major depressive disorder would greatly facilitate appropriate medical treatments, as well as provide insight into etiology. Reduced activity of the cAMP signaling system has been implicated in the etiology of major depression. Previous work has shown low adenylyl cyclase activity in platelets and postmortem brain tissue of depressed individuals. Here, we investigate the role of the brain type VII isoform of adenylyl cyclase (AC7) in the manifestation of depressive symptoms in genetically modified animals, using a combination of in vivo behavioral experiments, gene expression profiling, and bioinformatics. We also completed studies with humans on the association of polymorphisms in the AC7 gene with major depressive illness (unipolar depression) based on Diagnostic and Statistical Manual of Mental Disorders IV criteria. Collectively, our results demonstrate a sex-specific influence of the AC7 gene on a heritable form of depressive illness.