PT  - JOURNAL ARTICLE
AU  - Empson, Ruth M.
AU  - Garside, Molly L.
AU  - Knöpfel, Thomas
TI  - Plasma Membrane Ca<sup>2+</sup> ATPase 2 Contributes to Short-Term Synapse Plasticity at the Parallel Fiber to Purkinje Neuron Synapse
AID  - 10.1523/JNEUROSCI.0069-07.2007
DP  - 2007 Apr 04
TA  - The Journal of Neuroscience
PG  - 3753--3758
VI  - 27
IP  - 14
4099  - http://www.jneurosci.org/content/27/14/3753.short
4100  - http://www.jneurosci.org/content/27/14/3753.full
SO  - J. Neurosci.2007 Apr 04; 27
AB  - Plasma membrane Ca2+ ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca2+ and Ca2+ excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA2−/− knock-out mice all point to its importance for cerebellar circuit dynamics. Here, we provide direct functional evidence for the influence of presynaptic PMCA2-mediated Ca2+ extrusion for short-term plasticity at cerebellar parallel fiber to Purkinje neuron synapses. Dramatic structural alterations to the Purkinje neurons in the absence of PMCA2 also suggest a strong influence of this fast PMCA2 isoform for development and maintenance of cerebellar function.