RT Journal Article SR Electronic T1 Plasma Membrane Ca2+ ATPase 2 Contributes to Short-Term Synapse Plasticity at the Parallel Fiber to Purkinje Neuron Synapse JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 3753 OP 3758 DO 10.1523/JNEUROSCI.0069-07.2007 VO 27 IS 14 A1 Empson, Ruth M. A1 Garside, Molly L. A1 Knöpfel, Thomas YR 2007 UL http://www.jneurosci.org/content/27/14/3753.abstract AB Plasma membrane Ca2+ ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca2+ and Ca2+ excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA2−/− knock-out mice all point to its importance for cerebellar circuit dynamics. Here, we provide direct functional evidence for the influence of presynaptic PMCA2-mediated Ca2+ extrusion for short-term plasticity at cerebellar parallel fiber to Purkinje neuron synapses. Dramatic structural alterations to the Purkinje neurons in the absence of PMCA2 also suggest a strong influence of this fast PMCA2 isoform for development and maintenance of cerebellar function.