TY - JOUR T1 - Determining the Neural Substrates of Goal-Directed Learning in the Human Brain JF - The Journal of Neuroscience JO - J. Neurosci. SP - 4019 LP - 4026 DO - 10.1523/JNEUROSCI.0564-07.2007 VL - 27 IS - 15 AU - Vivian V. Valentin AU - Anthony Dickinson AU - John P. O'Doherty Y1 - 2007/04/11 UR - http://www.jneurosci.org/content/27/15/4019.abstract N2 - Instrumental conditioning is considered to involve at least two distinct learning systems: a goal-directed system that learns associations between responses and the incentive value of outcomes, and a habit system that learns associations between stimuli and responses without any link to the outcome that that response engendered. Lesion studies in rodents suggest that these two distinct components of instrumental conditioning may be mediated by anatomically distinct neural systems. The aim of the present study was to determine the neural substrates of the goal-directed component of instrumental learning in humans. Nineteen human subjects were scanned with functional magnetic resonance imaging while they learned to choose instrumental actions that were associated with the subsequent delivery of different food rewards (tomato juice, chocolate milk, and orange juice). After training, one of these foods was devalued by feeding the subject to satiety on that food. The subjects were then scanned again, while being re-exposed to the instrumental choice procedure (in extinction). We hypothesized that regions of the brain involved in goal-directed learning would show changes in their activity as a function of outcome devaluation. Our results indicate that neural activity in one brain region in particular, the orbitofrontal cortex, showed a strong modulation in its activity during selection of a devalued compared with a nondevalued action. These results suggest an important contribution of orbitofrontal cortex in guiding goal-directed instrumental choices in humans. ER -