PT  - JOURNAL ARTICLE
AU  - Richard Belvindrah
AU  - Sabine Hankel
AU  - John Walker
AU  - Bruce L. Patton
AU  - Ulrich Müller
TI  - β1 Integrins Control the Formation of Cell Chains in the Adult Rostral Migratory Stream
AID  - 10.1523/JNEUROSCI.2991-06.2007
DP  - 2007 Mar 07
TA  - The Journal of Neuroscience
PG  - 2704--2717
VI  - 27
IP  - 10
4099  - http://www.jneurosci.org/content/27/10/2704.short
4100  - http://www.jneurosci.org/content/27/10/2704.full
SO  - J. Neurosci.2007 Mar 07; 27
AB  - The subventricular zone (SVZ) of the lateral ventricle is the major site of neurogenesis in the adult brain. Neuroblasts that are born in the SVZ migrate as chains along the rostral migratory stream (RMS) to the olfactory bulb. Little is known about the mechanisms that control interactions between neuroblasts during their migration. Here we show that migrating neuroblasts express β1integrins and that the integrin ligand laminin is localized to cell chains. Using genetically modified mice and time-lapse video recordings of SVZ explants, we demonstrate that β1 integrins and laminin promote the formation of cell chains. Laminin also induces the aggregation of purified neuroblasts. We conclude that the formation of cell chains in the RMS is controlled in part by β1 integrins via binding to laminin. In addition, we provide evidence that β1 class integrins are required for the maintenance of the glial tubes and that defects in the glial tubes lead to the ectopic migration of neuroblasts into the surrounding tissue.