RT Journal Article
SR Electronic
T1 Conservation of Glutamate Receptor 2-Containing AMPA Receptors during Long-Term Potentiation
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 4598
OP 4602
DO 10.1523/JNEUROSCI.0325-07.2007
VO 27
IS 17
A1 Adesnik, Hillel
A1 Nicoll, Roger A.
YR 2007
UL http://www.jneurosci.org/content/27/17/4598.abstract
AB Long-term potentiation (LTP) at hippocampal synapses is thought to involve the insertion of AMPA receptors into the postsynaptic membrane. Conflicting evidence exists as to whether calcium-permeable receptors are inserted during LTP and whether synaptic activity mediated by the newly inserted AMPA receptors is required to maintain the increase in synaptic strength. Here, we rigorously test these hypotheses and conclude that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained.