PT  - JOURNAL ARTICLE
AU  - Martin A. Sieber
AU  - Robert Storm
AU  - Margaret Martinez-de-la-Torre
AU  - Thomas Müller
AU  - Hagen Wende
AU  - Katja Reuter
AU  - Elena Vasyutina
AU  - Carmen Birchmeier
TI  - Lbx1 Acts as a Selector Gene in the Fate Determination of Somatosensory and Viscerosensory Relay Neurons in the Hindbrain
AID  - 10.1523/JNEUROSCI.0717-07.2007
DP  - 2007 May 02
TA  - The Journal of Neuroscience
PG  - 4902--4909
VI  - 27
IP  - 18
4099  - http://www.jneurosci.org/content/27/18/4902.short
4100  - http://www.jneurosci.org/content/27/18/4902.full
SO  - J. Neurosci.2007 May 02; 27
AB  - Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.