PT  - JOURNAL ARTICLE
AU  - Castro, Jason B.
AU  - Hovis, Kenneth R.
AU  - Urban, Nathaniel N.
TI  - Recurrent Dendrodendritic Inhibition of Accessory Olfactory Bulb Mitral Cells Requires Activation of Group I Metabotropic Glutamate Receptors
AID  - 10.1523/JNEUROSCI.0613-07.2007
DP  - 2007 May 23
TA  - The Journal of Neuroscience
PG  - 5664--5671
VI  - 27
IP  - 21
4099  - http://www.jneurosci.org/content/27/21/5664.short
4100  - http://www.jneurosci.org/content/27/21/5664.full
SO  - J. Neurosci.2007 May 23; 27
AB  - Metabotropic glutamate receptors (mGluRs) modulate neural excitability and network tone in many brain regions. Expression of mGluRs is particularly high in the accessory olfactory bulb (AOB), a CNS structure critical for detecting chemicals that identify kin and conspecifics. Because of its relative simplicity and its direct projection to the hypothalamus, the AOB provides a model system for studying how mGluRs affect the flow of encoded sensory information to downstream areas. We investigated the role of group I mGluRs in synaptic processing in AOB slices and found that under control conditions, recurrent inhibition of principal neurons (mitral cells) was completely eliminated by the mGluR1 antagonist LY367385 [(S)-(+)-α-amino-4-carboxy-2 methylbenzeneacetic acid]. In addition, the group I mGluR agonist DHPG [(S)-3,5-dihydroxyphenylglycine; 20 μm] induced a dramatic increase in the rate of spontaneous IPSCs. This increase was dependent on voltage-gated calcium channels but persisted even after blockade of ionotropic glutamatergic transmission and sodium channels. Together, these results indicate that mGluR1 plays a critical role in controlling information flow through the AOB and suggest that mGluR1 may be an important locus for experience-dependent changes in synaptic function.