RT Journal Article
SR Electronic
T1 Role of the Primate Amygdala in Fear-Potentiated Startle: Effects of Chronic Lesions in the Rhesus Monkey
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 7386
OP 7396
DO 10.1523/JNEUROSCI.5643-06.2007
VO 27
IS 28
A1 Elena A. Antoniadis
A1 James T. Winslow
A1 Michael Davis
A1 David G. Amaral
YR 2007
UL http://www.jneurosci.org/content/27/28/7386.abstract
AB In experiment 1, we assessed the role of the primate amygdala and hippocampus in the acquisition of learned fear measured with fear-potentiated startle. Three groups of six rhesus monkeys were prepared with bilateral ibotenic acid lesions of the amygdaloid complex and the hippocampus or were sham operated. Selective ibotenic acid lesions of the amygdala, but not the hippocampus, blocked the acquisition of fear-potentiated startle. In experiment 2, we assessed the role of the primate amygdala in the expression of fear-potentiated startle. Surprisingly, animals that sustained amygdala damage after they successfully learned fear-potentiated startle expressed normal fear-potentiated startle, despite a complete amygdala lesion based on magnetic resonance imaging assessments. These results suggest that although the amygdala is necessary for the initial acquisition of fear-potentiated startle, it is not necessary for the retention and expression of fear-potentiated startle. These findings are discussed in relation to the role of the amygdala in emotional learning and in cross-species comparisons of emotional behavior.