TY - JOUR T1 - An Ion Channel Essential for Sensing Chemical Damage JF - The Journal of Neuroscience JO - J. Neurosci. SP - 11412 LP - 11415 DO - 10.1523/JNEUROSCI.3600-07.2007 VL - 27 IS - 42 AU - Lindsey J. Macpherson AU - Bailong Xiao AU - Kelvin Y. Kwan AU - Matt J. Petrus AU - Adrienne E. Dubin AU - SunWook Hwang AU - Benjamin Cravatt AU - David P. Corey AU - Ardem Patapoutian Y1 - 2007/10/17 UR - http://www.jneurosci.org/content/27/42/11412.abstract N2 - Tissue damage and its downstream consequences are experimentally assayed by formaldehyde application, which indiscriminately modifies proteins and is presumed to cause pain through broadly acting mechanisms. Here we show that formaldehyde activates the ion channel TRPA1 and that TRPA1-deficient mice exhibit dramatically reduced formaldehyde-induced pain responses. 4-Hydroxynonenal, a reactive chemical produced endogenously during oxidative stress, and other related aldehydes also activate TRPA1 in vitro. Furthermore, painful responses to iodoacetamide, a nonspecific cysteine-alkylating compound, are abolished in TRPA1-deficient mice. Therefore, although these reactive chemicals modify many proteins, the associated pain appears mainly dependent on a single ion channel. ER -