RT Journal Article
SR Electronic
T1 Noncoding RNAs in the Brain
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 11856
OP 11859
DO 10.1523/JNEUROSCI.3624-07.2007
VO 27
IS 44
A1 Satterlee, John S.
A1 Barbee, Scott
A1 Jin, Peng
A1 Krichevsky, Anna
A1 Salama, Sofie
A1 Schratt, Gerhard
A1 Wu, Da-Yu
YR 2007
UL http://www.jneurosci.org/content/27/44/11856.abstract
AB Cells transcribe thousands of RNAs that do not appear to encode proteins. The neuronal functions of these noncoding RNAs (ncRNAs) are for the most part not known, but specific ncRNAs have been shown to regulate dendritic spine development, neuronal fate specification and differentiation, and synaptic protein synthesis. ncRNAs have been implicated in a number of neuronal diseases including Tourette's syndrome and Fragile X syndrome. Future studies will likely identify additional neuronal functions for ncRNAs as well as roles for these molecules in other neuropsychiatric and neurodevelopmental disorders.