RT Journal Article SR Electronic T1 Connected Corticospinal Sites Show Enhanced Tuning Similarity at the Onset of Voluntary Action JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 12349 OP 12357 DO 10.1523/JNEUROSCI.3127-07.2007 VO 27 IS 45 A1 Yuval Yanai A1 Nofya Adamit A1 Ran Harel A1 Zvi Israel A1 Yifat Prut YR 2007 UL http://www.jneurosci.org/content/27/45/12349.abstract AB Corticospinal (CS) pathways provide the structural foundation for executing voluntary movements. Although the anatomy of these pathways is well explored, little is known about spinal decoding of parametric information transmitted via this route during voluntary movements. We addressed this question by simultaneously recording cortical and spinal activity in primates performing an isometric wrist task with multiple targets while measuring CS interactions. Single-pulse cortical stimulation effectively produced a short-latency (presumably monosynaptic) spinal response and thus revealed functionally connected CS sites. Spinal and cortical neurons recorded from connected CS sites showed alignment of directional-torque tuning that peaked at torque onset, consistent with the enhanced cortical drive active during this period. This increased tuning similarity was accompanied by an increased trial-to-trial covariability of firing. Whereas functional CS interactions were dynamic, the efficacy of cortical stimulation was unaffected by the motor state. These results suggest that around the onset of motor action there is a period of facilitated information transfer during which cortical command has greater efficacy in recruiting spinal neurons with matching tuning properties. Dynamic alignment of response properties may form the basis for a spinal readout mechanism of descending motor commands in which directional-torque is a parameter that is preserved across interacting CS sites.