%0 Journal Article %A Bin Jiang %A Mario TreviƱo %A Alfredo Kirkwood %T Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex %D 2007 %R 10.1523/JNEUROSCI.2655-07.2007 %J The Journal of Neuroscience %P 9648-9652 %V 27 %N 36 %X Visual deprivation affects the responses of layer IV cells more prominently during early postnatal development, whereas responses in layer II/III remain modifiable until later ages. We examined whether these laminar differences correlate with changes in long-term potentiation (LTP) and long-term depression (LTD) of the ascending pathways to layers IV and II/III in the mouse visual cortex. Our analysis revealed that LTP and LTD in layer IV principal cells is lost shortly after the eyes open, but persists in layers II/III beyond puberty. These results suggest that plasticity proceeds sequentially through cortical layers in a manner that parallels the flow of information during sensory processing. %U https://www.jneurosci.org/content/jneuro/27/36/9648.full.pdf