RT Journal Article
SR Electronic
T1 Targeting Cre Recombinase to Specific Neuron Populations with Bacterial Artificial Chromosome Constructs
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9817
OP 9823
DO 10.1523/JNEUROSCI.2707-07.2007
VO 27
IS 37
A1 Gong, Shiaoching
A1 Doughty, Martin
A1 Harbaugh, Carroll R.
A1 Cummins, Alexander
A1 Hatten, Mary E.
A1 Heintz, Nathaniel
A1 Gerfen, Charles R.
YR 2007
UL http://www.jneurosci.org/content/27/37/9817.abstract
AB Transgenic mouse lines are characterized with Cre recombinase driven by promoters of CNS-specific genes using bacterial artificial chromosome (BAC) constructs. BAC-Cre constructs for 10 genes (Chat, Th, Slc6a4, Slc6a2, Etv1, Ntsr1, Drd2, Drd1, Pcp2, and Cmtm5) produced 14 lines with Cre expression in specific neuronal and glial populations in the brain. These Cre driver lines add functional utility to the >500 BAC-EGFP (enhanced green fluorescent protein) transgenic mouse lines that are part of the Gene Expression Nervous System Atlas Project.