RT Journal Article
SR Electronic
T1 Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 791
OP 795
DO 10.1523/JNEUROSCI.4152-06.2007
VO 27
IS 4
A1 Joseph F. Cheer
A1 Kate M. Wassum
A1 Leslie A. Sombers
A1 Michael L. A. V. Heien
A1 Jennifer L. Ariansen
A1 Brandon J. Aragona
A1 Paul E. M. Phillips
A1 R. Mark Wightman
YR 2007
UL http://www.jneurosci.org/content/27/4/791.abstract
AB Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB1) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders.