PT  - JOURNAL ARTICLE
AU  - Joshua W. Buckholtz
AU  - Andreas Meyer-Lindenberg
AU  - Robyn A. Honea
AU  - Richard E. Straub
AU  - Lukas Pezawas
AU  - Michael F. Egan
AU  - Radhakrishna Vakkalanka
AU  - Bhaskar Kolachana
AU  - Beth A. Verchinski
AU  - Steven Sust
AU  - Venkata S. Mattay
AU  - Daniel R. Weinberger
AU  - Joseph H. Callicott
TI  - Allelic Variation in <em>RGS4</em> Impacts Functional and Structural Connectivity in the Human Brain
AID  - 10.1523/JNEUROSCI.5112-06.2007
DP  - 2007 Feb 14
TA  - The Journal of Neuroscience
PG  - 1584--1593
VI  - 27
IP  - 7
4099  - http://www.jneurosci.org/content/27/7/1584.short
4100  - http://www.jneurosci.org/content/27/7/1584.full
SO  - J. Neurosci.2007 Feb 14; 27
AB  - Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of Gα-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia susceptibility factor. Using a multimodal neuroimaging approach, we demonstrate that genetic variation in RGS4 is associated with functional activation and connectivity during working memory in the absence of overt behavioral differences, with regional gray and white matter volume and with gray matter structural connectivity in healthy human subjects. Specifically, variation at one RGS4 single nucleotide polymorphism that has been associated previously with psychosis (rs951436) impacts frontoparietal and frontotemporal blood oxygenation level-dependent response and network coupling during working memory and results in regionally specific reductions in gray and white matter structural volume in individuals carrying the A allele. These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness.