RT Journal Article SR Electronic T1 Allelic Variation in RGS4 Impacts Functional and Structural Connectivity in the Human Brain JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 1584 OP 1593 DO 10.1523/JNEUROSCI.5112-06.2007 VO 27 IS 7 A1 Joshua W. Buckholtz A1 Andreas Meyer-Lindenberg A1 Robyn A. Honea A1 Richard E. Straub A1 Lukas Pezawas A1 Michael F. Egan A1 Radhakrishna Vakkalanka A1 Bhaskar Kolachana A1 Beth A. Verchinski A1 Steven Sust A1 Venkata S. Mattay A1 Daniel R. Weinberger A1 Joseph H. Callicott YR 2007 UL http://www.jneurosci.org/content/27/7/1584.abstract AB Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of Gα-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia susceptibility factor. Using a multimodal neuroimaging approach, we demonstrate that genetic variation in RGS4 is associated with functional activation and connectivity during working memory in the absence of overt behavioral differences, with regional gray and white matter volume and with gray matter structural connectivity in healthy human subjects. Specifically, variation at one RGS4 single nucleotide polymorphism that has been associated previously with psychosis (rs951436) impacts frontoparietal and frontotemporal blood oxygenation level-dependent response and network coupling during working memory and results in regionally specific reductions in gray and white matter structural volume in individuals carrying the A allele. These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness.