RT Journal Article
SR Electronic
T1 Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2349
OP 2356
DO 10.1523/JNEUROSCI.5587-06.2007
VO 27
IS 9
A1 William W. Seeley
A1 Vinod Menon
A1 Alan F. Schatzberg
A1 Jennifer Keller
A1 Gary H. Glover
A1 Heather Kenna
A1 Allan L. Reiss
A1 Michael D. Greicius
YR 2007
UL http://www.jneurosci.org/content/27/9/2349.abstract
AB Variations in neural circuitry, inherited or acquired, may underlie important individual differences in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to isolate and characterize two distinct networks typically coactivated during functional MRI tasks. We identified a “salience network,” anchored by dorsal anterior cingulate (dACC) and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an “executive-control network” that links dorsolateral frontal and parietal neocortices. These intrinsic connectivity networks showed dissociable correlations with functions measured outside the scanner. Prescan anxiety ratings correlated with intrinsic functional connectivity of the dACC node of the salience network, but with no region in the executive-control network, whereas executive task performance correlated with lateral parietal nodes of the executive-control network, but with no region in the salience network. Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior.