RT Journal Article SR Electronic T1 Working Memory and the Organization of Brain Systems JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 4818 OP 4822 DO 10.1523/JNEUROSCI.0710-08.2008 VO 28 IS 18 A1 Shrager, Yael A1 Levy, Daniel A. A1 Hopkins, Ramona O. A1 Squire, Larry R. YR 2008 UL http://www.jneurosci.org/content/28/18/4818.abstract AB Working memory has historically been viewed as an active maintenance process that is independent of long-term memory and independent of the medial temporal lobe. However, impaired performance across brief time intervals has sometimes been described in amnesic patients with medial temporal lobe damage. These findings raise a fundamental question about how to know when performance depends on working memory and when the capacity for working memory has been exceeded and performance depends on long-term memory. We describe a method for identifying working memory independently of patient performance. We compared patients with medial temporal lobe damage to controls who were given either distraction or no distraction between study and test. In four experiments, we found concordance between the performance of patients and the effect of distraction on controls. The patients were impaired on tasks in which distraction had minimal effect on control performance, and the patients were intact on tasks in which distraction disrupted control performance. We suggest that the patients were impaired when the task minimally depended on working memory (and instead depended substantially on long-term memory), and they performed well when the task depended substantially on working memory. These findings support the conclusion that working memory (active maintenance) is intact after medial temporal lobe damage.