PT  - JOURNAL ARTICLE
AU  - Court, Felipe A.
AU  - Hendriks, William T. J.
AU  - MacGillavry, Harold D.
AU  - Alvarez, Jaime
AU  - van Minnen, Jan
TI  - Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System
AID  - 10.1523/JNEUROSCI.2429-08.2008
DP  - 2008 Oct 22
TA  - The Journal of Neuroscience
PG  - 11024--11029
VI  - 28
IP  - 43
4099  - http://www.jneurosci.org/content/28/43/11024.short
4100  - http://www.jneurosci.org/content/28/43/11024.full
SO  - J. Neurosci.2008 Oct 22; 28
AB  - Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis.