RT Journal Article
SR Electronic
T1 Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 11024
OP 11029
DO 10.1523/JNEUROSCI.2429-08.2008
VO 28
IS 43
A1 Court, Felipe A.
A1 Hendriks, William T. J.
A1 MacGillavry, Harold D.
A1 Alvarez, Jaime
A1 van Minnen, Jan
YR 2008
UL http://www.jneurosci.org/content/28/43/11024.abstract
AB Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis.