RT Journal Article
SR Electronic
T1 Modes and Mishaps of Neuronal Migration in the Mammalian Brain
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 11746
OP 11752
DO 10.1523/JNEUROSCI.3860-08.2008
VO 28
IS 46
A1 Christine Métin
A1 Richard B. Vallee
A1 Pasko Rakic
A1 Pradeep G. Bhide
YR 2008
UL http://www.jneurosci.org/content/28/46/11746.abstract
AB The ability of neurons to migrate to their appropriate positions in the developing brain is critical to brain architecture and function. Recent research has elucidated different modes of neuronal migration and the involvement of a host of signaling factors in orchestrating the migration, as well as vulnerabilities of this process to environmental and genetic factors. Here we discuss the role of cytoskeleton, motor proteins, and mechanisms of nuclear translocation in radial and tangential migration of neurons. We will also discuss how these and other events essential for normal migration of neurons can be disrupted by genetic and environmental factors that contribute to neurological disease in humans.