PT  - JOURNAL ARTICLE
AU  - Qiang Shan
AU  - Guy C.-K. Chan
AU  - Daniel R. Storm
TI  - Type 1 Adenylyl Cyclase Is Essential for Maintenance of Remote Contextual Fear Memory
AID  - 10.1523/JNEUROSCI.2413-08.2008
DP  - 2008 Nov 26
TA  - The Journal of Neuroscience
PG  - 12864--12867
VI  - 28
IP  - 48
4099  - http://www.jneurosci.org/content/28/48/12864.short
4100  - http://www.jneurosci.org/content/28/48/12864.full
SO  - J. Neurosci.2008 Nov 26; 28
AB  - Although molecular mechanisms for hippocampus-dependent memory have been extensively studied, much less is known about signaling events important for remote memory. Here we report that mice lacking type 1 adenylyl cyclase (AC1) are able to establish and retrieve remote contextual memory but unable to sustain it as long as wild-type mice. Interestingly, mice overexpressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory.